منابع مشابه
Why endosomes recycle GPCRs
Bowman et al. provide a novel explanation for why activated G protein–coupled receptors (GPCRs) migrate from the cell surface to the endosomes (1). The study indicates that GPCRs that have moved to certain locations on endosomes activate specifi c genes—and thus presumably induce different cellular responses. GPCRs help us perceive our surroundings, control our blood pressure, mobilize our immu...
متن کاملWhy GPCRs behave differently in cubic and lamellar lipidic mesophases
Recent successes in the crystallographic determination of structures of transmembrane proteins in the G protein-coupled receptor (GPCR) family have established the lipidic cubic phase (LCP) environment as the medium of choice for growing structure-grade crystals by the method termed "in meso". The understanding of in meso crystallogenesis is currently at a descriptive level. To enable an eventu...
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Contrary to most other epithelia, trophoblasts in the human placenta, which form the physical barrier between the fetal and the maternal blood circulation, express high numbers of transferrin receptors on their apical cell surface. This study describes the establishment of a polarized trophoblast-like cell line BeWo, which exhibit a high expression of transferrin receptors on the apex of the ce...
متن کاملOrphan GPCRs and Neuromodulation
Most G protein-coupled receptors (GPCRs) started as orphan GPCRs. Matching them to known neuromodulators led to the elucidation of the broad diversity of the neuroreceptor families. Moreover, orphan GPCRs have also been used as targets to discover novel neuromodulators. These discoveries have had profound impact on our understanding of brain function. Here, I present an overview of how some of ...
متن کاملNeuropeptide GPCRs in Neuroendocrinology
G protein-coupled receptors (GPCRs) represent the single largest family of plasma membrane receptors, encompassing about 860 members in humans. During the last decades, considerable progress has been made regarding the biochemical identification, signaling mechanisms, allosteric modulation, structural characterization, and pathophysiological implication of GPCRs, which are considered as major t...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2016
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.2147if